Journal Article

Therapeutic Hypothermia Using Gel Packs for Term Neonates with Hypoxic Ischaemic Encephalopathy in Resource-limited Settings: a Randomized Controlled Trial

Shruthi K. Bharadwaj and B. Vishnu Bhat

in Journal of Tropical Pediatrics

Volume 58, issue 5, pages 382-388
Published in print October 2012 | ISSN: 0142-6338
Published online March 2012 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fms005
Therapeutic Hypothermia Using Gel Packs for Term Neonates with Hypoxic Ischaemic Encephalopathy in Resource-limited Settings: a Randomized Controlled Trial

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Objective: To evaluate the efficacy of therapeutic hypothermia (TH) using gel packs in reducing mortality and morbidity in term neonates with HIE and study the associated problems with TH.

Methods: Hypoxic ischaemic encephalopathy babies were randomized into TH and control group. Babies in TH group were cooled for first 72 h of birth using cloth covered cooling gel packs to maintain target rectal temperature of 33–34°C. Infants were followed up to 6 months and were assessed using Baroda Developmental Screening Test.

Results: There were no significant differences in baseline parameters. TH group showed significant reduction in the combined rate of death or developmental delay at 6 months of age by 21% (8.1% in the TH group vs. 29% in the control, RR 0.28, 95% CI: 0.11–0.70; p = 0.003).

Conclusions: TH using gel packs reduces the risk of death or developmental delay at 6 months of age in infants with HIE.

Trial registration number: CTRI/2011/06/001780.

Keywords: perinatal asphyxia; therapeutic hypothermia; cooling gel packs; hypoxic ischaemic encephalopathy; resource limited settings

Journal Article.  2462 words.  Illustrated.

Subjects: Paediatrics

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