Journal Article

Effect of Therapeutic Hypothermia on Oxidative Stress and Outcome in Term Neonates with Perinatal Asphyxia: A Randomized Controlled Trial

Rojo Joy, Femitha Pournami, Adhisivam Bethou, Vishnu B. Bhat and Zachariah Bobby

in Journal of Tropical Pediatrics

Volume 59, issue 1, pages 17-22
Published in print February 2013 | ISSN: 0142-6338
Published online August 2012 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fms036
Effect of Therapeutic Hypothermia on Oxidative Stress and Outcome in Term Neonates with Perinatal Asphyxia: A Randomized Controlled Trial

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Objectives: To evaluate in term babies with perinatal asphyxia, the effect of therapeutic hypothermia (TH) on oxidative stress and neurological outcome at discharge.

Methods: Babies who satisfied inclusion criteria were randomized to TH, with cooling gel packs to a target temperature of 33–34°C for 72 h or normothermia. Blood sample was collected before and after TH for oxidative stress assessment: total antioxidant status (TAS) and malondialdehyde (MDA).

Results: Of 116 babies randomized, there was no statistically significant difference in the baseline TAS and MDA. After 72 h of TH, TAS was significantly higher (p = <0.001) (761.69 ± 114.01 vs. 684.16 ± 88.86) and MDA was significantly lower (p = <0.001) in TH group (1.73 ± 0.66 vs. 5.2 ± 1.06). Risk of developing deficit was lower (p < 0.001) in TH group with relative risk of 0.49 and 95 % confidence interval: 0.29–0.68.

Conclusion: TH reduces oxidative stress and improves neurological outcome in perinatal asphyxia.

Trial registration number: CTRI/2011/12/002196.

Keywords: perinatal asphyxia; therapeutic hypothermia; oxidative stress; total antioxidant status; malondialdehyde

Journal Article.  2687 words.  Illustrated.

Subjects: Paediatrics

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