Journal Article

Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation

A. C. Liwa, H. S. Schaaf, B. Rosenkranz, H. I. Seifart, A. H. Diacon and P. R. Donald

in Journal of Tropical Pediatrics

Volume 59, issue 2, pages 90-94
Published in print April 2013 | ISSN: 0142-6338
Published online November 2012 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fms053
Para-Aminosalicylic Acid Plasma Concentrations in Children in Comparison with Adults after Receiving a Granular Slow-Release Preparation

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There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens pre-dose and 2, 4, 6, 8 and 12 h post-dose from the children and 2, 3, 4, 5, 6, 8 and 12 h post-dose from the adults were analysed by high performance liquid chromatography MS/MS. The mean Cmax in children receiving PAS 75 mg/kg and 150 mg/kg and adults receiving 4 g was 45.40, 56.49 and 51.3 µg/ml, respectively (p = 0.614); the AUC0–12 was 233.3, 277.9 and 368.0 µg/h/ml (p = 0.587). No parameters differed significantly between children and adults nor between the two doses in the same children. A 150 mg/kg PAS dosage given as one or two daily doses leads to plasma concentrations in children similar to those of adults receiving 4 g PAS twice daily.

Keywords: para-aminosalicylic acid; pharmacokinetics; children

Journal Article.  2641 words.  Illustrated.

Subjects: Paediatrics

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