Journal Article

Bubble CPAP versus Ventilator CPAP in Preterm Neonates with Early Onset Respiratory Distress—A Randomized Controlled Trial

Amit Tagare, Sandeep Kadam, Umesh Vaidya, Anand Pandit and Sanjay Patole

in Journal of Tropical Pediatrics

Volume 59, issue 2, pages 113-119
Published in print April 2013 | ISSN: 0142-6338
Published online January 2013 | e-ISSN: 1465-3664 | DOI: http://dx.doi.org/10.1093/tropej/fms061
Bubble CPAP versus Ventilator CPAP in Preterm Neonates with Early Onset Respiratory Distress—A Randomized Controlled Trial

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Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations.

Objective: To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress.

Methods: In a randomized controlled trial, preterm neonates with Silverman–Anderson score ≥4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared.

Results: In all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman–Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01).

Conclusion: BCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.

Keywords: bubble; CPAP; efficacy; neonates; preterm; ventilator

Journal Article.  3166 words.  Illustrated.

Subjects: Paediatrics

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