Journal Article

Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital

Lubaba Shahrin, Mohammad Jobayer Chisti, Sayeeda Huq, Thamanna Nishath, Maria D. Christy, Anika Hannan and Tahmeed Ahmed

in Journal of Tropical Pediatrics

Volume 62, issue 3, pages 206-212
Published in print June 2016 | ISSN: 0142-6338
Published online February 2016 | e-ISSN: 1465-3664 | DOI: https://dx.doi.org/10.1093/tropej/fmv100
Clinical Manifestations of Hyponatremia and Hypernatremia in Under-Five Diarrheal Children in a Diarrhea Hospital

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Objective: To study clinical manifestations and outcome of hyponatremia and hypernatremia in children with diarrhea.

Method: We compared children aged 0–59 months hospitalized from 1 January to 31 December 2013 with hyponatremia (serum sodium <130 mmol/l), hypernatremia (serum sodium >150 mmol/l) and normonatremia (serum sodium 135–145 mmol/l).

Results: The case fatality was significantly higher among the children with hypernatremia and hyponatremia than normonatremia. A logistic regression analysis adjusting for potential confounders revealed that children with hyponatremia are more likely to have convulsions, have severe acute malnutrition and be of older age compared with children with normal serum sodium. Children with hypernatremia are more likely to have convulsions and dehydration than normonatremic children (for all p < 0.05).

Conclusion: Early diagnosis and prompt management of hypo- and hypernatremia by identifying simple clinical predicting factors of these two conditions in diarrheal children <5 years of age is critically important to prevent deaths in such children, especially in resource-limited settings.

Keywords: children; deaths; diarrhea; hypernatremia; hyponatremia

Journal Article.  2989 words.  Illustrated.

Subjects: Paediatrics

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