Journal Article

Decreased <i>in vivo</i> virulence and altered gene expression by a <i>Brucella melitensis</i> light-sensing histidine kinase mutant

Christopher R. Gourley, Erik Petersen, Jerome Harms and Gary Splitter

Edited by Eric Oswald

in Pathogens and Disease

Volume 73, issue 2, pages 1-8
Published in print March 2015 |
Published online February 2015 | e-ISSN: 2049-632X | DOI: http://dx.doi.org/10.1111/2049-632X.12209

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This well-written research article reports the genome-scale microarray analysis of a light-sensing histidine kinase mutant of Brucella melitensis. Results of the analysis indicate that the expression of 243 genes is altered and that some of these genes encode well-known virulence factors, a finding confirmed by the observed attenuated virulence of the mutant in experimentally infected C57BL/6 mice. The findings provide evidence that a light-sensing kinase is at the top (or near the top) of a regulatory hierarchy of genes involved in virulence, metabolism and stress response.

Keywords: brucellosis; flagella; stress; LOV; virB; PhyR

Journal Article.  4590 words.  Illustrated.

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