Journal Article

Potentiation of lethal endotoxin shock by streptococcal pyrogenic exotoxin in rabbits: Possible relevance of hyperreactivity of macrophages to endotoxin

Toshimi Murai, Yukari Nakagawa and Yoshiyuki Ogawa

in FEMS Immunology & Medical Microbiology

Volume 13, issue 4, pages 269-272
Published in print April 1996 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: http://dx.doi.org/10.1111/j.1574-695X.1996.tb00250.x
Potentiation of lethal endotoxin shock by streptococcal pyrogenic exotoxin in rabbits: Possible relevance of hyperreactivity of macrophages to endotoxin

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Abstract

Streptococcal pyrogenic exotoxin (SPE) potentiates lethal shock induced by endotoxin. We have previously reported that macrophages derived from SPE-treated rabbits showed hyperreactivity to endotoxin, and that the effect of SPE on macrophages was mediated by a lymphokine(s). Here we show that culture supernatants of SPE-stimulated lymphocytes, when administered into rabbits three hours before or together with endotoxin, potentiate a variety of endotoxin-induced pathophysiological changes and even lethal shock. These results suggest that SPE-induced lymphokine(s) mediates the potentiating effect of SPE on the lethal endotoxin shock through enhancing endotoxin reactivity of macrophages which play the central role in mediating endotoxin toxicity.

Keywords: Streptococcal pyrogenic exotoxin; Endotoxin shock; Macrophage; Lymphokine

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