Journal Article

Abstract

Katsuhiko Matsui

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 24, issue 1, pages 97-103
Published in print May 1999 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: http://dx.doi.org/10.1111/j.1574-695X.1999.tb01270.x
Abstract

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Abstract

In this study, it was found that macrophages from Salmonella-infected mice expressed the interleukin-2 receptor (IL-2R). The IL-2R induced by the infection consisted mainly of both β and γ chains, and the expression of IL-2Rα was very low. Furthermore, similar expression of IL-2Rβ and γ chains was observed in interferon-γ-treated macrophages. The effect of recombinant interleukin-2 on the intracellular killing activity of macrophages which expressed IL-2Rβ and γ was then studied. Our results demonstrated that interleukin-2 acted synergistically with interferon-γ through the IL-2R in the induction of macrophage intracellular killing activity and established a new role of IL-2R on bactericidal activity of macrophages.

Keywords: Salmonella typhimurium; Macrophage; Interleukin-2; Interferon-γ; Interleukin-2 receptor

Journal Article.  2091 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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