Journal Article

Animal models used to test the interactions between infectious agents and products of cigarette smoked implicated in sudden infant death syndrome

Nicola M. Sayers and David B. Drucker

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 25, issue 1-2, pages 115-123
Published in print August 1999 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: http://dx.doi.org/10.1111/j.1574-695X.1999.tb01334.x
Animal models used to test the interactions between infectious agents and products of cigarette smoked implicated in sudden infant death syndrome

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Abstract

Animal test systems are reviewed that have relevance to sudden infant death syndrome (SIDS) are reviewed. These test interactions between infectious agents (or their toxins) and products of cigarette smoke. Infectious agents implicated in SIDS include members of the enterobacteria and clostridia, Staphylococcus aureus and Streptococcus pyogenes. Smoking is thought to be the single most preventable cause of SIDS. Tobacco smoke contains many extremely toxic products including cyanide and nicotine. Many animal test systems are available to examine the potency of bacterial toxins and smoke-derived components. These include mice, hamsters, rats and chick embryos. Such systems reveal synergy between bacterial toxins, especially endotoxin and superantigens. They have also demonstrated potentiation of low levels of bacterial toxin by low levels of both nicotine and its primary metabolite, cotinine. These findings suggest a possible causal explanation for the fact that passive exposure to cigarette smoke is a risk factor in sudden infant death syndrome.

Keywords: Sudden infant death syndrome; Microbiology; Smoking; Animal model

Journal Article.  5331 words. 

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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