Journal Article

Dectin-1 mediates <i>in vitro</i> phagocytosis of <i>Candida albicans</i> yeast cells by retinal microglia

Victoria Maneu, Alberto Yáñez, Celia Murciano, Andrés Molina, María Luisa Gil and Daniel Gozalbo

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 63, issue 1, pages 148-150
Published in print October 2011 | ISSN: 0928-8244
Published online September 2011 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.2011.00829.x
Dectin-1 mediates in vitro phagocytosis of Candida albicans yeast cells by retinal microglia

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Abstract

We have investigated the expression of TLR2 and Dectin-1 in retinal microglia and their involvement in Candida albicans phagocytosis using a cytometric approach. The expression of both receptors has been demonstrated in CD11b+ retinal cells. Phagocytosis of pHrodo-labelled C. albicans yeasts by microglial CD11b+ cells of C57BL/6 mice was inhibited both by the Dectin-1 antagonist laminarin and anti-Dectin-1 antibodies, whereas phagocytosis of yeasts by retinal microglia of TLR2 KO mice was unaffected. These data indicate that phagocytosis of C. albicans yeasts by retinal microglia is mediated by Dectin-1, whereas TLR2 does not play a significant role in this process.

Keywords: Candida albicans; retinal microglia; Dectin-1; TLR2; phagocytosis; flow cytometry

Journal Article.  1540 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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