Journal Article

Combating biofilms

Liang Yang, Yang Liu, Hong Wu, Zhijun Song, Niels Høiby, Søren Molin and Michael Givskov

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 65, issue 2, pages 146-157
Published in print July 2012 | ISSN: 0928-8244
Published online June 2012 | e-ISSN: 1574-695X | DOI: http://dx.doi.org/10.1111/j.1574-695X.2011.00858.x
Combating biofilms

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Abstract

Biofilms are complex microbial communities consisting of microcolonies embedded in a matrix of self-produced polymer substances. Biofilm cells show much greater resistance to environmental challenges including antimicrobial agents than their free-living counterparts. The biofilm mode of life is believed to significantly contribute to successful microbial survival in hostile environments. Conventional treatment, disinfection and cleaning strategies do not proficiently deal with biofilm-related problems, such as persistent infections and contamination of food production facilities. In this review, strategies to control biofilms are discussed, including those of inhibition of microbial attachment, interference of biofilm structure development and differentiation, killing of biofilm cells and induction of biofilm dispersion.

Keywords: biofilm; resistance; attachment; development; inhibition; dispersion

Journal Article.  6897 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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