Journal Article

Arginase-1 expression in granulomas of tuberculosis patients

Ana P. Pessanha, Rodrigo A.P. Martins, Ana L. Mattos-Guaraldi, Albanita Vianna and Lilian O. Moreira

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 66, issue 2, pages 265-268
Published in print November 2012 | ISSN: 0928-8244
Published online October 2012 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.2012.01012.x
Arginase-1 expression in granulomas of tuberculosis patients

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Abstract

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen able to survive and multiply within macrophages. Several mechanisms allow this bacterium to escape macrophage microbicidal activity. Mtb may interfere with the ability of mouse macrophages to produce antibactericidal nitric oxide, by inducing the expression of arginase 1 (Arg1). It remains unclear whether this pathway has a role in humans infected with Mtb. In this study, we investigated the expression of Arg1 in granulomas of human lung tissues from patients with tuberculosis. We show that Arg1 is expressed not only in granuloma-associated macrophages, but also in type II pneumocytes.

Keywords: arginase-1; macrophages; type II pneumocytes; Mycobacterium

Journal Article.  2140 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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