Journal Article

Impact of <i>sar</i> and <i>agr</i> on methicillin resistance in <i>Staphylococcus aureus</i>

S.Píriz Durán, F.H. Kayser and B. Berger-Bächi

in FEMS Microbiology Letters

Volume 141, issue 2-3, pages 255-260
Published in print August 1996 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI:

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The global regulators agr and sar control expression of cell wall and extracellular proteins. Inactivation of either sar and/or agr in a typical heterogeneously methicillin-resistant Staphylococcus aureus resulted in a small but reproducible decrease in the number of cells in the subpopulation expressing high methicillin resistance. The amount of low affinity penicillin-binding protein PBP2′, the prerequisite for methicillin resistance, was apparently not affected, however, a reduction in PBP1 and PBP3 production was observed, suggesting that these resident PBPs of the cells might be involved somehow together with PBP2′ in high level methicillin resistance.

Keywords: Global regulator; Penicillin-binding protein; PBP1; PBP3; mecA; Staphylococcus aureus

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