Journal Article

Polyamine metabolism in the thermotolerant mesophilic fungus <i>Aspergillus fumigatus</i>

Dale R Walters, Tracey Cowley and Arlene McPherson

in FEMS Microbiology Letters

Volume 153, issue 2, pages 433-437
Published in print August 1997 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI:

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Biomass production by Aspergillus fumigatus was greatest at 40–45°C and was associated with an increase in concentration of the diamine putrescine and activity of its biosynthetic enzyme ornithine decarboxylase. Concentrations of the other amines, cadaverine, spermidine and spermine were considerably lower than putrescine concentration and did not change significantly over the temperature range 20–50°C. This is surprising in view of the greatly increased flux of label from ornithine through to spermidine at 45 and 50°C, indicating an increased formation of this triamine. It is suggested that there was increased formation of spermidine derivatives at these temperatures. Interestingly, there was greatly increased formation of the higher homologues of cadaverine, aminopropylcadaverine and N,N′-bis(3-aminopropyl)cadaverine, in A. fumigatus at 45 and 50°C.

Keywords: Polyamine; Cadaverine derivative; Polyamine biosynthesis; Aspergillus fumigatus

Journal Article.  2289 words.  Illustrated.

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