Journal Article

Insertional inactivation of a Tet(K)/Tet(L) like transporter does not eliminate tetracycline resistance in <i>Bacillus cereus</i>

Ole Andreas Økstad, Anne Grønstad, Toril Lindbäck and Anne-Brit Kolstø

in FEMS Microbiology Letters

Volume 154, issue 2, pages 181-186
Published in print September 1997 |
Published online January 2006 | e-ISSN: 1574-6968 | DOI:

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Bacillus cereus ATCC 10987 and ATCC 14579 can be induced to high levels of resistance to tetracycline. The chromosomal B. cereus gene bctl encodes a transmembrane protein with homology to Gram-positive tetracycline efflux proteins and relation to other members of the major facilitator superfamily of transport proteins. A mutant strain containing an insertionally inactivated bctl gene did not show impaired tetracycline resistance. No additional altered phenotype was observed in the mutant. Accumulation studies suggested that the resistance mechanism involves a reduced sensitivity to intracellular tetracycline.

Keywords: Tetracycline resistance; Major facilitator superfamily; Active efflux; Transport; Bacillus cereus

Journal Article.  3099 words.  Illustrated.

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