Journal Article

Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

Kathy Musa-Veloso, Malcolm Angus Binns, Alexandra Catherine Kocenas, Theresa Poon, Julie Ann Elliot, Harry Rice, Hilde Oppedal-Olsen, Hilary Lloyd and Shawna Lemke

in Nutrition Reviews

Volume 68, issue 3, pages 155-167
Published in print March 2010 | ISSN: 0029-6643
Published online October 2014 | e-ISSN: 1753-4887 | DOI: http://dx.doi.org/10.1111/j.1753-4887.2010.00272.x
Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

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The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200–500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200–500 mg/day are 3.1 to 7.2%.

Keywords: docosahexaenoic acid; eicosapentaenoic acid; fish oil; omega-3 fatty acids; triglycerides

Journal Article.  8036 words.  Illustrated.

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