Journal Article

Effect of whole grains on markers of subclinical inflammation

Michael Lefevre and Satya Jonnalagadda

in Nutrition Reviews

Volume 70, issue 7, pages 387-396
Published in print July 2012 | ISSN: 0029-6643
Published online October 2014 | e-ISSN: 1753-4887 | DOI:
Effect of whole grains on markers of subclinical inflammation

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The reduction of subclinical inflammation has been suggested as a potential mechanism to explain the favorable association between whole-grain consumption and reduced risk for cardiovascular disease, diabetes, and certain cancers. This review examines evidence for the effects of whole-grain consumption on markers of subclinical inflammation derived from 13 epidemiological and 5 interventional studies retrieved from a search of the PubMed database. Epidemiological studies provide reasonable support for an association between diets high in whole grains and lower C-reactive protein (CRP) concentrations. After adjusting for other dietary factors, each serving of whole grains is estimated to reduce CRP concentrations by approximately 7%. In contrast to epidemiological studies, interventional studies do not demonstrate a clear effect of increased whole-grain consumption on CRP or other markers of inflammation. Issues related to insufficient length of intervention, extent of dietary control, population selection, types of whole grains, and lack of a direct anti-inflammatory effect may underlie these discrepant findings. Additional carefully controlled interventional studies are needed to clarify the effects of whole grains on subclinical inflammation.

Keywords: C-reactive protein; inflammation; interleukin-6; whole grains

Journal Article.  5846 words.  Illustrated.

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