Journal Article

Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults

Matthew M Robinson, Val J Lowe and K Sreekumaran Nair

in The Journal of Clinical Endocrinology & Metabolism

Published on behalf of Endocrine Society

Volume 103, issue 1, pages 221-227
ISSN: 0021-972X
Published online October 2017 | e-ISSN: 1945-7197 | DOI: https://dx.doi.org/10.1210/jc.2017-01571
Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults

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  • Medicine and Health
  • Clinical Medicine
  • Endocrinology and Diabetes
  • Medical Oncology
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Abstract

Context

Aerobic exercise training can increase brain volume and blood flow, but the impact on brain metabolism is less known.

Objective

We determined whether high-intensity interval training (HIIT) increases brain metabolism by measuring brain glucose uptake in younger and older adults.

Design

Brain glucose uptake was measured before and after HIIT or a sedentary (SED) control period within a larger exercise study.

Setting

Study procedures were performed at the Mayo Clinic in Rochester, MN.

Participants

Participants were younger (18 to 30 years) or older (65 to 80 years) SED adults who were free of major medical conditions. Group sizes were 15 for HIIT (nine younger and six older) and 12 for SED (six younger and six older).

Intervention

Participants completed 12 weeks of HIIT or SED. HIIT was 3 days per week of 4 × 4 minute intervals at over 90% of peak aerobic capacity (VO2peak) with 2 days per week of treadmill walking at 70% VO2peak.

Main Outcome Measures

Resting brain glucose uptake was measured using 18F-fluorodeoxyglucose positron emission tomography scans at baseline and at week 12. Scans were performed at 96 hours after exercise. VO2peak was measured by indirect calorimetry.

Results

Glucose uptake increased significantly in the parietal-temporal and caudate regions after HIIT compared with SED. The gains with HIIT were not observed in all brain regions. VO2peak was increased for all participants after HIIT and did not change with SED.

Conclusion

We demonstrate that brain glucose metabolism increased after 12 weeks of HIIT in adults in regions where it is reduced in Alzheimer’s disease.

Journal Article.  4858 words.  Illustrated.

Subjects: Medicine and Health ; Clinical Medicine ; Endocrinology and Diabetes ; Medical Oncology ; Reproductive Medicine

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