Journal Article

Acquisition-weighted MRSI for Detection and Quantification of BNCT <sup>10</sup>B-carrier L-<i>p</i>-boronophenylalanine-fructose Complex, a Phantom Study

Marjut Timonen, Leena Kankaanranta, Nina Lundbom, Mika Kortesniemi, Tiina SeppäLä, Mauri Kouri, Sauli Savolainen and Sami Heikkinen

in Journal of Radiation Research

Volume 50, issue 5, pages 435-440
Published in print September 2009 | ISSN: 0449-3060
Published online July 2009 | e-ISSN: 1349-9157 | DOI: http://dx.doi.org/10.1269/jrr.08127
Acquisition-weighted MRSI for Detection and Quantification of BNCT 10B-carrier L-p-boronophenylalanine-fructose Complex, a Phantom Study

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  • Clinical Genetics
  • Molecular Biology and Genetics
  • Epidemiology
  • Radiology
  • Nuclear Chemistry, Photochemistry, and Radiation

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Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the brain. However, optimal positioning of MRS voxel to capture tissue with maximal BPA concentration can be challenging. Three dimensional proton magnetic resonance spectroscopic imaging (3D 1H MRSI) provides spectral data covering a large spatial volume, which is a major advantage in detecting and quantifying BPA. BPA detection limit in phantom conditions was determined at 1.5 T using a 3D 1H MRSI protocol with clinically acceptable nominal spatial resolution and duration. Quantification tests for aqueous phantom were performed using both single voxel MRS and 3D MRSI. In 3D MRSI, BPA detection limit was ~1.0 mM and BPA quantification accuracy was better than ±5%. The results suggest that MRSI would be a feasible method for in vivo BPA evaluation in clinical conditions.

Keywords: Spectroscopic imaging; MRSI; BNCT; BPA-F

Journal Article.  0 words. 

Subjects: Clinical Genetics ; Molecular Biology and Genetics ; Epidemiology ; Radiology ; Nuclear Chemistry, Photochemistry, and Radiation

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