Journal Article

Ghrelin: Update 2003

in Nutrition Reviews

Volume 61, issue 3, pages 101-104
Published in print March 2003 | ISSN: 0029-6643
Published online September 2014 | e-ISSN: 1753-4887 | DOI: https://dx.doi.org/10.1301/nr.2003.marr.101-104
Ghrelin: Update 2003

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Ghrelin is a recently described peptide hormone that is secreted by endocrine cells in the gastrointestinal tract. Although its initial discovery was as a novel growth hormone secretagogue, it has been found to regulate feeding behavior by modulating expression levels of orexigenic peptides in the hypothalamus. Ghrelin has been implicated in the coordination of energy balance and weight regulation, and its dysregulation may be important in obesity. Ghrelin also has several other physiologic actions besides potential regulation of food intake that are described in this brief review.

Keywords: ghrelin; peptide; hormone; energy; regulation; obesity

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