Journal Article

Absence of TLR4 Asp299Gly and Thr399Ile Polymorphisms in Chinese Han Population With Type 2 Diabetes

Peng-bin Lai, Lei Zhang, Sun-jie Yan and Li-yong Yang

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 41, issue 9, pages 559-562
Published in print September 2010 | ISSN: 0007-5027
Published online October 2015 | e-ISSN: 1943-7730 | DOI: http://dx.doi.org/10.1309/LMXOLM087ICXXCSE
Absence of TLR4 Asp299Gly and Thr399Ile Polymorphisms in Chinese Han Population With Type 2 Diabetes

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  • Clinical Cytogenetics and Molecular Genetics
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

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Objective:

This study was performed to detect the association between the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene and type 2 diabetes in the Chinese Han population.

Methods:

The study included 856 unrelated individuals with type 2 diabetes and 672 healthy controls. The polymorphisms of the TLR4 gene were examined through denaturing high-performance liquid chromatography.

Results:

Neither the Asp299Gly nor the Thr399Ile polymorphism was detected in any of the diabetic and healthy subjects.

Conclusions:

Our finding indicates the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene are very rare in the Chinese Han population.

Keywords: toll-like receptor 4; polymorphism; type 2 diabetes

Journal Article.  1715 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics ; Molecular and Cell Biology ; Molecular Biology and Genetics

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