Chapter

Lucké Renal Adenocarcinoma

Robert G. Mckinnell and Debra L. Carlson

in Amphibian Declines

Published by University of California Press

Published in print June 2005 | ISBN: 9780520235922
Published online March 2012 | e-ISBN: 9780520929432 | DOI: http://dx.doi.org/10.1525/california/9780520235922.003.0017
Lucké Renal Adenocarcinoma

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The Lucké renal adenocarcinoma of northern leopard frogs (Rana pipiens) was originally described by Balduin Lucké during the 1930s. The depletion of frog populations has been a major concern of herpetologists worldwide. One study has investigated the cell biology of the Lucké renal adenocarcinoma since 1958. Early in these studies, it became obvious that the best way to obtain frog renal adenocarcinomas for experimental studies was to study frogs in natural populations. In retrospect, it seems curious that an investigation into the cell biology of a frog neoplasm would lead to early recognition of frog population declines. The history of the Lucké renal adenocarcinoma of northern leopard frogs is impressive in that these studies led to the notions that herpesviruses can cause cancer, that there was a problem with frog populations in the upper Midwest, and that differentiation therapy may lead to a new form of cancer treatment. This chapter reviews past and present investigations of the Lucké renal adenocarcinoma that afflicts northern leopard frogs. It examines the pathology, epidemiology, and etiology of the Lucké renal adenocarcinoma.

Keywords: Lucké renal adenocarcinoma; northern leopard frogs; Rana pipiens; Balduin Lucké; cell biology; population declines; differentiation therapy; pathology; epidemiology; etiology

Chapter.  4836 words.  Illustrated.

Subjects: Zoology and Animal Sciences

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