Experimental Evolution from the Bottom Up

Daniel E. Dykhuizen and Anthony M. Dean

in Experimental Evolution

Published by University of California Press

Published in print March 2009 | ISBN: 9780520247666
Published online March 2012 | e-ISBN: 9780520944473 | DOI:
Experimental Evolution from the Bottom Up

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This chapter focuses on the bottom-up approach used to understand the nature of natural selection, and begins by discussing a bottom-up analysis of the lactose system. The study of lactose metabolism by Escherichia coli provides a tractable experimental system where mechanistic predictions about the direction and intensity of selection can be tested decisively. The chapter also illustrates other ways in which bottom-up experiments in evolution can be done. They can be used to study glucose metabolism in Drosophila and the genotype-phenotype map for single genes. The bottom-up approach can also be used to examine the similarities and differences in vision for organisms in different environments.

Keywords: bottom-up approach; natural selection; lactose metabolism; Escherichia coli; glucose metabolism; Drosophila

Chapter.  7621 words.  Illustrated.

Subjects: Evolutionary Biology

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