Sequence Alignment

Edited by Michael Rosenberg

Published by University of California Press

Published in print November 2009 | ISBN: 9780520256972
Published online March 2012 | e-ISBN: 9780520943742 | DOI:
Sequence Alignment

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The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning them—making sure that sequences from one source are properly compared to those from others—remains a complicated but underappreciated aspect of comparative molecular biology. This book, whic focuses on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and, more importantly, how the outcomes of any alignment algorithm should be interpreted. It covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Keywords: human genome; molecular biology; alignment; alignment algorithms; alignment underpinnings; computational advances

Book.  360 pages.  Illustrated.

Subjects: Evolutionary Biology

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Sequence Alignment in Sequence Alignment


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