Chapter

Insertion and Deletion Events, Their Molecular Mechanisms, and Their Impact on Sequence Alignments

Liam J. Mcguffin

in Sequence Alignment

Published by University of California Press

Published in print November 2009 | ISBN: 9780520256972
Published online March 2012 | e-ISBN: 9780520943742 | DOI: http://dx.doi.org/10.1525/california/9780520256972.003.0002
Insertion and Deletion Events, Their Molecular Mechanisms, and Their Impact on Sequence Alignments

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This chapter discusses the molecular mechanisms leading to indel (insertion and deletion) mutations and explains how these events affect how score sequence alignments are carried out, exploring the root causes of indel events that allow for better approaches to context-dependent alignment. It begins by looking at a sequence alignment in order to illustrate the problem of handling insertions and deletions in related sequences. The chapter then discusses the different types of mutation that may occur at the DNA level and the resulting effects which these different types have on the translated protein sequence. The proposed mechanisms of indel formation and the impact of indels on sequence alignments are also examined.

Keywords: molecular mechanisms; indel; insertion; deletion; mutations; sequence alignments; indel formation

Chapter.  4681 words.  Illustrated.

Subjects: Evolutionary Biology

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