Chapter

Computing Multiple Sequence Alignment with Template-Based Methods

Cédric Notredame

in Sequence Alignment

Published by University of California Press

Published in print November 2009 | ISBN: 9780520256972
Published online March 2012 | e-ISBN: 9780520943742 | DOI: http://dx.doi.org/10.1525/california/9780520256972.003.0004
Computing Multiple Sequence Alignment with Template-Based Methods

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This chapter examines the major approaches for multiple sequence alignment (MSA), including matrix- and consistency-based approaches, and focuses on the latest developments, including the development of meta-methods and the emergence of template-based alignment techniques. It also considers the effect of reference benchmarks on the recent development of MSA packages, and their potential shortcomings.

Keywords: multiple sequence alignment; MSA; matrix-based approaches; consistency-based approaches; meta-methods; template-based alignment

Chapter.  4948 words.  Illustrated.

Subjects: Evolutionary Biology

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