Journal Article

Absence of TLR2 influences survival of neutrophils after infection with <i>Candida albicans</i>

Venessa Tessarolli, Thaís Helena Gasparoto, Hayana Ramos Lima, Eduardo Aleixo Figueira, Thiago Pompermaier Garlet, Sérgio Aparecido Torres, Gustavo Pompermaier Garlet, João Santana Da Silva and Ana Paula Campanelli

in Medical Mycology

Published on behalf of International Society for Human and Animal Mycology

Volume 48, issue 1, pages 129-140
Published in print February 2010 | ISSN: 1369-3786
Published online February 2010 | e-ISSN: 1460-2709 | DOI: http://dx.doi.org/10.3109/13693780902964339
Absence of TLR2 influences survival of neutrophils after infection with Candida albicans

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  • Mycology and Fungi
  • Infectious Diseases
  • Medical Toxicology
  • Veterinary Medicine
  • Environmental Science

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Candida albicans is an opportunistic pathogen, which causes local and/or disseminated diseases in immunosuppressed humans. Phagocytic cells play a critical role in the immune response against C. albicans. Toll like receptors (TLR) are important in the identification of invading microorganisms and in the regulation of neutrophil survival. TLR2 has been shown to participate in the response against pathogenic yeasts and to increase the functional life span of neutrophils. In view of these observations, we studied the involvement of TLR2 in neutrophil function after C. albicans infection. The absence of TLR2 resulted in lower chemotaxis of neutrophils to the site of infection. This in turn was associated with lower levels of chemokines from neutrophils, facilitating the dissemination of the pathogen to the lymph nodes and spleen. A high frequency of apoptotic neutrophils and macrophages in the inflammatory exudates from TLR2−/− mice was found. In addition, the phagocytic activity of neutrophils and macrophages, nitric oxide production and myeloperoxidase activity were diminished in cells from TLR2−/− mice. Together, these data demonstrate the importance of TLR2 signals for neutrophils activation and survival after C. albicans infection.

Keywords: TLR2; innate response; Candida albicans

Journal Article.  5972 words.  Illustrated.

Subjects: Mycology and Fungi ; Infectious Diseases ; Medical Toxicology ; Veterinary Medicine ; Environmental Science

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