Journal Article

A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines

Sriram Krishnamoorthy, Candace D. Smith, Adnan A. Al-Rubaye, Gisela F. Erf, Robert F. Wideman, Nicholas B. Anthony and Douglas D. Rhoads

in Poultry Science

Published on behalf of Poultry Science Association Inc.

Volume 93, issue 2, pages 307-317
Published in print February 2014 | ISSN: 0032-5791
Published online January 2014 | e-ISSN: 1525-3171 | DOI: http://dx.doi.org/10.3382/ps.2013-03359
A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines

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A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.

Keywords: ascites; hypertension; quantitative trait locus; commercial broiler

Journal Article.  6152 words.  Illustrated.

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