Chapter

Single Neuron Correlates of Declarative Memory Formation and Retrieval in the Human Medial Temporal Lobe

Itzhak Fried

in Single Neuron Studies of the Human Brain

Published by The MIT Press

Published in print July 2014 | ISBN: 9780262027205
Published online January 2015 | e-ISBN: 9780262323994 | DOI: http://dx.doi.org/10.7551/mitpress/9780262027205.003.0007
Single Neuron Correlates of Declarative Memory Formation and Retrieval in the Human Medial Temporal Lobe

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The assessment of stimulus novelty is a pre-requisite for many kinds of learning. Here, we summarize research on the representation of novelty-and familiarity by individual neurons in the human MTL. These neurons express single-trial learning, i.e. they change their response after a single response. The response strength of these neurons is continuously related to memory strength. We further describe a study that shows that individual MTL neurons phase-lock to ongoing theta rhythms and that the strength of such phase locking during learning is predictive of later memory strength.

Keywords: Hippocampus; Amygdala; Declarative memory; episodic memory

Chapter.  9335 words.  Illustrated.

Subjects: Neuroscience

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