Journal Article

SUPPRESSION OF SYMPTOMS OF ALCOHOL DEPENDENCE AND CRAVING USING HIGH-DOSE BACLOFEN

WILLIAM BUCKNAM

in Alcohol and Alcoholism

Published on behalf of Medical Council on Alcohol

Volume 42, issue 2, pages 158-160
Published in print March 2007 | ISSN: 0735-0414
Published online December 2006 | e-ISSN: 1464-3502 | DOI: http://dx.doi.org/10.1093/alcalc/agl091
SUPPRESSION OF SYMPTOMS OF ALCOHOL DEPENDENCE AND CRAVING USING HIGH-DOSE BACLOFEN

Show Summary Details

Preview

Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.

Journal Article.  1865 words. 

Subjects: Public Health and Epidemiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.