• Four-fifths of the cervical cancer burden is in the developing world where there is a lack of effective screening. • The potential to reduce cervical cancer by human papilloma virus (HPV) vaccination in developing countries is challenged by cost and lack of effective vaccine delivery platforms for children and adolescents. • Other challenges include the following: • Sensitivities of using a vaccine preventing an STI in girls • Lack of awareness, public demand, and political will • Lack of coordination between cancer control, sexual/reproductive health, and vaccine delivery services. •...

• Four-fifths of the cervical cancer burden is in the developing world where there is a lack of effective screening. • The potential to reduce cervical cancer by human papilloma virus (HPV) vaccination in developing countries is challenged by cost and lack of effective vaccine delivery platforms for children and adolescents. • Other challenges include the following: • Sensitivities of using a vaccine preventing an STI in girls • Lack of awareness, public demand, and political will • Lack of coordination between cancer control, sexual/reproductive health, and vaccine delivery services. • Local production of vaccines at reduced cost, logistically feasible efficacious vaccine regimes, and strengthening vaccine delivery infrastructure for children and adolescents will be required for successful HPV vaccination in developing countries. •