A family of proteins (CLIC proteins, ~240–250 aa) expressed in a wide variety of tissues that may have diverse functions in addition to their role as chloride channels. They are expressed in the nucleus and in cytoplasmic locations. CLIC1 is primarily expressed in the nucleus, CLIC5 interacts with the cortical actin cytoskeleton in placental microvilli. Members of the family include parchorin and bovine p64.
Subjects: Medicine and Health.