Journal Article

Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania

Michele D. Hastings, Sarah J. Bates, Eric A. Blackstone, Stephanie M. Monks, Theonest K. Mutabingwa and Carol Hopkins Sibley

in Transactions of The Royal Society of Tropical Medicine and Hygiene

Published on behalf of Royal Society of Tropical Medicine and Hygiene

Volume 96, issue 6, pages 674-676
Published in print December 2002 | ISSN: 0035-9203
Published online December 2002 | e-ISSN: 1878-3503 | DOI: https://dx.doi.org/10.1016/S0035-9203(02)90349-4
Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania

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  • Clinical Medicine
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In 2000 we used a sensitive technique to examine 9 isolates from malaria patients in Muheza, Tanzania who had failed treatment with sulfadoxine-pyrimethamine (SP). Three isolates carried, at low levels, the leucine to isoleucine change at amino acid 164 that is associated with clinical failure of SP. Numerous other highly resistant alleles were also observed.

Keywords: malaria; Plasmodium falciparum; chemotherapy; drug resistance; antimalarial drugs; antifolate; Tanzania

Journal Article.  0 words. 

Subjects: Clinical Medicine ; Infectious Diseases ; Immunology ; Medical Microbiology and Virology ; Public Health and Epidemiology

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