Journal Article

Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum

S. Picot, J. Burnod, V. Bracchi, B.F.F. Chumpitazi and P. Ambroise-Thomas

in Transactions of The Royal Society of Tropical Medicine and Hygiene

Published on behalf of Royal Society of Tropical Medicine and Hygiene

Volume 91, issue 5, pages 590-591
Published in print October 1997 | ISSN: 0035-9203
Published online October 1997 | e-ISSN: 1878-3503 | DOI: https://dx.doi.org/10.1016/S0035-9203(97)90039-0
Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum

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Abstract

As chemoresistance of Plasmodium falciparum to chloroquine has arisen, new ways of combating the infection are needed. Similarities exist between the multidrug resistance of mammalian cells and chloroquine resistance of P. falciparum, based on the occurrence of internucleosomal deoxyribonucleic acid (DNA) breakdown and the ability of some anticancer drugs and chloroquine to induce apoptosis. Using chloroquine, oligonucleosomal DNA fragmentation was observed with a sensitive strain of P. falciparum, but not with a resistant one. This suggests that apoptosis may be involved in the action of chloroquine on the parasite.

Keywords: malaria; Plasmodium falciparum; chloroquine resistance; apoptosis

Journal Article.  0 words. 

Subjects: Clinical Medicine ; Infectious Diseases ; Immunology ; Medical Microbiology and Virology ; Public Health and Epidemiology

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