Journal Article

Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria

Ruth Aguilar, Sonia Machevo, Clara Menéndez, Azucena Bardají, Augusto Nhabomba, Pedro L. Alonso and Alfredo Mayor

in Transactions of The Royal Society of Tropical Medicine and Hygiene

Published on behalf of Royal Society of Tropical Medicine and Hygiene

Volume 106, issue 9, pages 573-575
Published in print September 2012 | ISSN: 0035-9203
Published online September 2012 | e-ISSN: 1878-3503 | DOI: https://dx.doi.org/10.1016/j.trstmh.2012.05.001
Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria

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  • Clinical Medicine
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Monitoring interventions to prevent malaria in pregnancy requires sensitive detection of placental infection. Rapid diagnostic tests (RDTs) are good candidates, but little information is available on their sensitivity on placental blood. We have evaluated the agreement (kappa coefficient) between microscopy and a Plasmodium falciparum histidine-rich protein 2 (HRP2)-based immuno-chromatographic test (ICT) on placental blood from 1151 women at delivery. Prevalences of placental infection by microscopy and RDT were 5.1% and 5.0%, respectively, showing 82.9% agreement (p < 0.0001). Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery.

Keywords: Malaria; Placenta; Microscopy; HRP2; RDT; Mozambique

Journal Article.  1275 words.  Illustrated.

Subjects: Clinical Medicine ; Infectious Diseases ; Immunology ; Medical Microbiology and Virology ; Public Health and Epidemiology

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