Journal Article

Whole genome comparison of the A. fumigatus family

J. R. Wortman, N. Fedorova, J. Crabtree, V. Joardar, R. Maiti, B. J. Haas, P. Amedeo, E. Lee, S. V. Angiuoli, B. Jiang, M. J. Anderson, D. W. Denning, O. R. White and W. C. Nierman

in Medical Mycology

Published on behalf of International Society for Human and Animal Mycology

Volume 44, issue Supplement_1, pages S3-S7
Published in print September 2006 | ISSN: 1369-3786
Published online September 2006 | e-ISSN: 1460-2709 | DOI: https://dx.doi.org/10.1080/13693780600835799
Whole genome comparison of the A. fumigatus family

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  • Mycology and Fungi
  • Infectious Diseases
  • Medical Toxicology
  • Veterinary Medicine
  • Environmental Science

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The availability of the genome sequences of multiple Aspergillus spp. presents the research community with an unprecedented opportunity for discovery. The genomes of Neosartorya fischeri and Aspergillus clavatus have been sequenced in order to extend our knowledge of Aspergillus fumigatus, the primary cause of invasive aspergillosis. Through comparative genomic analysis, we hope to elucidate both obvious and subtle differences between genomes, developing new hypotheses that can be tested in the laboratory. A preliminary examination of the genomes and their predicted proteomes reveals extensive conservation between protein sequences and significant synteny, or conserved gene order. Comparative genomic analysis at the level of these closely related aspergilli should provide important insight into the evolutionary forces at play and their effect on gene content, regulation and expression.

Keywords: Aspergillus; aspergillosis; genome; synteny

Journal Article.  2083 words.  Illustrated.

Subjects: Mycology and Fungi ; Infectious Diseases ; Medical Toxicology ; Veterinary Medicine ; Environmental Science

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