Journal Article

Bacille Calmette-Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3-Dioxygenase in Mice

Maïté Moreau, Jacques Lestage, Danièle Verrier, Cécile Mormède, Keith W. Kelley, Robert Dantzer and Nathalie Castanon

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 192, issue 3, pages 537-544
Published in print August 2005 | ISSN: 0022-1899
Published online August 2005 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/431603
Bacille Calmette-Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3-Dioxygenase in Mice

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

BackgroundActivation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link in the relationship between cytokines and depression. We aimed to develop an experimental model of chronic IDO activation based on bacille Calmette-Guérin (BCG) infection that elicits a robust increase in levels of interferon (IFN)–γ, a key cytokine in the activation of IDO

MethodsMice were inoculated intraperitoneally with BCG (107 cfu/mouse). Lung and brain IDO activity was measured over time, together with plasma levels of TRP and IFN-γ

ResultsBCG induced, over the course of several weeks, a chronic increase in serum IFN-γ levels that was associated with a sustained enhancement of lung and brain IDO activity and with decreases in peripheral (serum and lungs) and brain concentrations of TRP, with different time courses between tissues

ConclusionsThe model of BCG-induced IDO activation will be useful for the study of the consequences of peripheral immune activation in the brain and the role of TRP metabolism in cytokine-induced mood alteration

Journal Article.  5237 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.