Journal Article

Severity of Respiratory Syncytial Virus Infection Is Related to Virus Strain

Edward E. Walsh, Kenneth M. McConnochie, Christine E. Long and Caroline B. Hall

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 175, issue 4, pages 814-820
Published in print April 1997 | ISSN: 0022-1899
Published online April 1997 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1086/513976
Severity of Respiratory Syncytial Virus Infection Is Related to Virus Strain

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The relationship between respiratory syncytial virus (RSV) strain and disease severity was assessed in 265 hospitalized infants over a 3-year period (1988–1991). A severity index of clinical and physiologic parameters was used to grade illness severity. Multivariate analysis of 134 infants infected with group A RSV strains and 131 infants infected with group B strains indicated that prematurity, underlying medical conditions, group A RSV infection, and age ⩽3 months were independently associated with severe disease. Odds ratios for severe disease for these risk factors were 1.83, 2.84, 3.26, and 4.39, respectively. Among infants without underlying medical conditions, group B RSV infection rarely required ventilatory support, in contrast to group A infections (1/90 vs. 13/107; P < .006), and had significantly lower severity indices (mean ± SD, 0.6 ± 9 vs. 1.3 ± 1.9; P = .05). Results confirm earlier findings that group A RSV infection results in greater disease severity than group B infection among hospitalized infants.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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