Reference Entry

temperature-sensitive mutation

John Lackie

in A Dictionary of Biomedicine

Published in print January 2010 | ISBN: 9780199549351
Published online January 2010 | e-ISBN: 9780191727948
temperature-sensitive mutation

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A conditional mutation (ts mutation), one that is only expressed at certain temperatures, usually because the nonpermissive temperature causes conformational instability in an essential protein. By shifting cells in culture to the permissive temperature the gene is ‘switched’ on or off, depending on the temperature-sensitive gene involved....

Reference Entry.  49 words. 

Subjects: Clinical Medicine

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