Journal Article

The Association Between Serum Activin A Levels and Hypertension in the Elderly: A Cross-Sectional Analysis From I-Lan Longitudinal Aging Study

Yi-Lin Tsai, Chun-Chin Chang, Li-Kuo Liu, Po-Hsun Huang, Liang-Kung Chen and Shing-Jong Lin

in American Journal of Hypertension

Volume 31, issue 3, pages 369-374
Published in print February 2018 | ISSN: 0895-7061
Published online November 2017 | e-ISSN: 1941-7225 | DOI: https://dx.doi.org/10.1093/ajh/hpx185
The Association Between Serum Activin A Levels and Hypertension in the Elderly: A Cross-Sectional Analysis From I-Lan Longitudinal Aging Study

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  • Endocrinology and Diabetes
  • Biochemistry
  • Neuroendocrinology and Autonomic Nervous System

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Abstract

BACKGROUND

Hypertension is an important risk factor for cardiovascular disease. Activin A, a member of the transforming growth factor-β cytokine family, has been shown to regulate blood pressure through the renin–angiotensin system. However, the relationship between activin A and blood pressure remains uncertain. The objective of this study was to determine whether serum activin A levels are associated with blood pressure.

METHOD

A total of 470 participants of I-Lan longitudinal Aging Study (ILAS) were eligible for this study. Serum levels of activin A were assessed by enzyme-linked immunosorbent assay. Cross-sectional analyses were performed, including comparisons of demographic characteristics, hypertensive status, and activin A levels.

RESULTS

Among the study participants (50% men, mean age, 69 years), 236 (50.2%) were hypertensive and 234 (49.8%) were normotensive. Hypertensive patients had significantly higher serum activin A levels than normotensives (normotensive vs. hypertensive: 507 ± 169 vs. 554 ± 176 pg/ml, mean ± SD, P < 0.001). All subjects were divided into 3 tertiles on the basis of serum activin A levels. Increasing tertiles of activin A were associated with higher systolic blood pressure (SBP), diastolic blood pressure and pulse pressure (PP) (all P < 0.001). After adjusting for all the potential confounding factors, serum activin A concentration was still significantly associated with SBP (P = 0.02) and PP (P = 0.03).

CONCLUSIONS

Serum activin A level was associated with SBP and PP. Further studies are required to assess their causal relationship and the clinical relevance.

Keywords: activin A; blood pressure; hypertension

Journal Article.  3604 words. 

Subjects: Endocrinology and Diabetes ; Biochemistry ; Neuroendocrinology and Autonomic Nervous System

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