Journal Article

ROS1 fusions in Chinese patients with non-small-cell lung cancer

W. Cai, X. Li, C. Su, L. Fan, L. Zheng, K. Fei, C. Zhou, C. Manegold and G. Schmid-Bindert

in Annals of Oncology

Published on behalf of European Society for Medical Oncology

Volume 24, issue 7, pages 1822-1827
Published in print July 2013 | ISSN: 0923-7534
Published online March 2013 | e-ISSN: 1569-8041 | DOI: https://dx.doi.org/10.1093/annonc/mdt071
ROS1 fusions in Chinese patients with non-small-cell lung cancer

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Background

To determine the prevalence and clinicopathological features of ROS1 fusions in Chinese patients with non-small-cell lung cancer (NSCLC).

Methods

Formalin-fixed and paraffin-embedded (FFPE) tissue sections from 392 patients with NSCLC were screened for ROS1 fusions by multiplex RT–PCR and all ROS1 fusions were validated by direct sequencing. The relationship between ROS1 fusions and clinicopathological features and the prognostic effect of the ROS1 fusion status on survival were analyzed.

Results

In this study, 8 of 392 (2.0%) evaluable samples were found to harbor ROS1 fusions. Of the ROS1-positive patients, seven presented with adenocarcinoma, and one with adenosquamous carcinoma. The ratio of female to male and never smoker to smokers in a ROS1 fusion-positive group was 5:3. There was no statistically significant difference in age, sex, smoking history, histological type and pathological stage between ROS1 fusion-positive and ROS1 fusion-negative patients. ROS1 fusion-negative patients had a significantly longer survival when compared with ROS1 fusion-positive patients (P = 0.041). Lower pathological stage, younger age and ROS1 fusion-negative status were significantly associated with better prognosis on multivariate analysis.

Conclusions

ROS1 fusions occurred in ∼2.0% of Chinese patients with NSCLC and had no specific clinicopathological feature. ROS1 fusion-negative patients may have a better survival than ROS1 fusion-positive patients.

Keywords: fusion; non-small-cell lung cancer; oncogenic driver; ROS1; rearrangement

Journal Article.  3688 words.  Illustrated.

Subjects: Medical Oncology

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