Journal Article

Enoximone pharmacokinetics in infants

P. D. Booker, S. Gibbons, J. I. M. Stewart, A. Selby, E. Wilson‐Smith and M. Pozzi

in BJA: British Journal of Anaesthesia

Published on behalf of the British Journal of Anaesthesia

Volume 85, issue 2, pages 205-210
Published in print August 2000 | ISSN: 0007-0912
Published online August 2000 | e-ISSN: 1471-6771 | DOI: https://dx.doi.org/10.1093/bja/85.2.205
Enoximone pharmacokinetics in infants

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Enoximone and enoximone sulphoxide concentrations were measured in plasma of 20 infants, median age 6.0 (range 0.6–49.7) weeks, during and after prolonged continuous infusions. Patients were given enoximone 1 mg kg–1 and an infusion at 10 µg kg–1 min–1 just before being weaned from cardiopulmonary bypass (CPB). The infusion was stopped when clinically indicated, after a median 97 (range 24–572) h. Arterial blood samples were taken 30 min and 12 h after CPB, every 24 h during the infusion, and then 2, 4, 8, 12 and 24 h after the infusion was stopped. Pharmacokinetic non‐compartmental analysis was performed using TOPFIT software. Fourteen patients who retained normal hepatic function had a median (95% confidence intervals) clearance of 9.7 (6.3–14.1) ml min–1 kg–1, elimination half‐life of 5.2 (2.4–6.8) h and a volume of distribution of 3.6 (2.0–5.7) litre kg–1. The six patients with significant hepatic dysfunction had a lower clearance, 5.7 (2.4–14.5) ml min–1 kg–1, and significantly longer elimination half‐life, 7.6 (6.5–10.9) h (P=0.02). Enoximone sulphoxide elimination half‐life was significantly prolonged in three patients with renal dysfunction, 16.2 (10.5–17.7) h versus 6.9 (6.1–9.4) h (P=0.03). These results confirm that enoximone pharmacokinetics in infants is similar to that found in adults. The infusion rate of enoximone should be reduced if hepatic or renal dysfunction supervenes.

Br J Anaesth 2000; 85: 205–10

Keywords: Keywords: pharmacokinetics; enoximone; infants; cardiac surgery

Journal Article.  4217 words.  Illustrated.

Subjects: Anaesthetics

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