Journal Article

Blood propofol concentration and psychomotor effects on driving skills

S. A. Grant, J. Murdoch, K. Millar and G. N. C. Kenny

in BJA: British Journal of Anaesthesia

Published on behalf of the British Journal of Anaesthesia

Volume 85, issue 3, pages 396-400
Published in print September 2000 | ISSN: 0007-0912
Published online September 2000 | e-ISSN: 1471-6771 | DOI: https://dx.doi.org/10.1093/bja/85.3.396
Blood propofol concentration and psychomotor effects on driving skills

Show Summary Details

Preview

We studied psychomotor performance in 10 healthy volunteers during recovery after a target‐controlled infusion of propofol. Choice reaction time, dual task tracking with secondary reaction time and a within‐list recognition task were assessed at target blood propofol concentrations of 0.8, 0.4 and 0.2 µg ml–1. Performance was impaired most at the highest blood propofol concentration (choice reaction time increased by a mean of 247 ms and secondary reaction time by a mean of 178 ms). Choice reaction time and dual task tracking with secondary reaction time were the most sensitive and reliable methods of assessment (significant difference from baseline (P<0.05) at a propofol concentration of 0.2 µg ml–1 with choice and secondary reaction time testing). Within‐list recognition assessment of memory was not sufficiently sensitive at very low propofol concentrations. The impairment in choice and secondary reaction time with a blood propofol concentration of 0.2 µg ml–1 was less than that observed with a blood alcohol concentration of 50 mg 100 ml–1 and no greater than that observed with a blood alcohol concentration of 20 mg 100 ml–1 in a previous study involving healthy volunteers.

Br J Anaesth 2000; 85: 396–400

Keywords: Keywords: recovery; anaesthetics i.v., propofol

Journal Article.  2487 words.  Illustrated.

Subjects: Anaesthetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.