Journal Article

One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo

D. Obal, B. Preckel, H. Scharbatke, J. Müllenheim, F. Höterkes, V. Thämer and W. Schlack

in BJA: British Journal of Anaesthesia

Published on behalf of the British Journal of Anaesthesia

Volume 87, issue 6, pages 905-911
Published in print December 2001 | ISSN: 0007-0912
Published online December 2001 | e-ISSN: 1471-6771 | DOI:
One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo

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Volatile anaesthetics protect the heart against reperfusion injury. We investigated whether the cardioprotection induced by sevoflurane against myocardial reperfusion injury was concentration‐dependent. Fifty‐eight α‐chloralose anaesthetized rats were subjected to 25 min of coronary artery occlusion followed by 90 min of reperfusion. Sevoflurane was administered for the first 15 min of reperfusion at concentrations corresponding to 0.75 (n=11), 1.0 (n=11), 1.5 (n=13), or 2.0 MAC (n=12). Eleven rats served as untreated controls. Left ventricular peak systolic pressure (LVPSP, tipmanometer) and cardiac output (CO, flowprobe) was measured. Infarct size (IS, triphenyltetrazolium staining) was determined as percentage of the area at risk. Baseline LVPSP was 131 (126–135) mm Hg (mean (95% confidence interval)) and CO 33 (31–36) ml min–1, similar in all groups. During early reperfusion, sevoflurane reduced LVPSP in a concentration‐dependent manner to 78 (67–89)% of baseline at 0.75 MAC (not significant vs controls 99 (86–112)%), 71 (62–80)% at 1 MAC (P<0.05), 66 (49–83)% at 1.5 MAC (P<0.05) and 56 (47–65)% at 2 MAC (P<0.05). CO remained constant. While 0.75 MAC of sevoflurane had no effect on IS (34 (27–41)% of the area at risk) compared with controls (38 (31–45)%, P=0.83), 1.0 MAC reduced IS markedly to 23 (17–30)% (P<0.05). Increasing the concentration to 1.5 MAC (23 (17–30)%) and 2 MAC (23 (13–32)%, both P<0.05 vs controls) had no additional protective effect. One MAC sevoflurane protected against myocardial reperfusion injury. Increasing the sevoflurane concentration above 1 MAC resulted in no further protection.

Br J Anaesth 2001; 87: 905–11

Keywords: Keywords: anaesthetics volatile, sevoflurane; heart, reperfusion injury

Journal Article.  3615 words.  Illustrated.

Subjects: Anaesthetics

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