Background. Cardiac output (CO) can be measured using the pressure recording analytical method (PRAM), which is a new, less invasive technique allowing beat-by-beat stroke volume monitoring from the pressure signals recorded in femoral or radial arteries.
Methods. We investigated PRAM by comparing its cardiac output (PRAM-CO) with paired measurements obtained by electromagnetic flowmetry (EM-CO) and by standard thermodilution (ThD-CO) during various haemodynamic states in a swine model. Nine pigs were monitored with a pulmonary artery catheter and a femoral artery catheter at baseline, in a hyperdynamic state produced by administration of dobutamine and in a hypodynamic state induced by progressive exsanguination. Bland–Altman analysis was used.
Results. One hundred and eight paired cardiac output values over a range of EM-CO of 1.8–10.4 litre min−1 resulted. We found close agreement between the techniques. Mean bias between EM-CO and PRAM-CO was −0.03 litre min−1 (precision 0.58 litre min−1). The 95% limits of agreement were −0.61 to +0.55 litre min−1. Similar results between ThD-CO and PRAM-CO were found.
Conclusions. In a porcine model we have demonstrated accuracy of PRAM during various haemodynamic states. PRAM is a reliable tool to detect changes in cardiac output in pigs and has ability as a basic research tool.
Keywords: heart, cardiac output; measurement techniques, cardiac output; measurement techniques, pulse contour method; measurement techniques, thermodilution; model, pig
Journal Article. 4243 words. Illustrated.
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