Journal Article

High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

Ira M. Mostovaya, Muriel P.C. Grooteman, Carlo Basile, Andrew Davenport, Camiel L.M. de Roij van Zuijdewijn, Christoph Wanner, Menso J. Nubé and Peter J. Blankestijn

in Clinical Kidney Journal

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 8, issue 4, pages 368-373
Published in print August 2015 | ISSN: 1753-0784
Published online June 2015 | e-ISSN: 1753-0792 | DOI:

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Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.

Keywords: convection volume; costs; hemodiafiltration; mortality; safety

Journal Article.  4197 words. 

Subjects: Nephrology

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