Journal Article

PolyprOnline: polyproline helix II and secondary structure assignment database

Romain Chebrek, Sylvain Leonard, Alexandre G. de Brevern and Jean-Christophe Gelly

in Database

Volume 2014, issue ISSN: 0000-0000
Published online November 2014 | e-ISSN: 1758-0463 | DOI: https://dx.doi.org/10.1093/database/bau102

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The polyproline helix type II (PPII) is a regular protein secondary structure with remarkable features. Many studies have highlighted different crucial biological roles supported by this local conformation, e.g. in the interactions between biological macromolecules. Although PPII is less frequently present than regular secondary structures such as canonical alpha helices and beta strands, it corresponds to 3–10% of residues. Up to now, PPII is not assigned by most popular assignment tools, and therefore, remains insufficiently studied. PolyprOnline database is, therefore, dedicated to PPII structure assignment and analysis to facilitate the study of PPII structure and functional roles. This database is freely accessible from www.dsimb.inserm.fr/dsimb_tools/polyproline.

Journal Article.  3163 words.  Illustrated.

Subjects: Bioinformatics and Computational Biology ; Ecology and Conservation ; Evolutionary Biology

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