Journal Article

Development of a Short Questionnaire to Assess the Quality of Life in Crohn’s Disease and Ulcerative Colitis

Laith Alrubaiy, Wai-Yee Cheung, Phedra Dodds, Hayley Anne Hutchings, Ian Trevor Russell, Alan Watkins and John Gordon Williams

in Journal of Crohn's and Colitis

Published on behalf of European Crohn's and Colitis Organisation

Volume 9, issue 1, pages 66-76
Published in print January 2015 | ISSN: 1873-9946
Published online December 2014 | e-ISSN: 1876-4479 | DOI: https://dx.doi.org/10.1093/ecco-jcc/jju005
Development of a Short Questionnaire to Assess the Quality of Life in Crohn’s Disease and Ulcerative Colitis

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  • Gastro-intestinal and Colorectal Surgery
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Background and aims:

Most of the disease-specific quality of life (QoL) measures for inflammatory bowel disease (IBD) are lengthy and time consuming. None have been established for routine use in clinical practice. We designed this study to develop a short QoL measure in IBD.

Methods:

A 32-item questionnaire, the Crohn’s and ulcerative colitis questionnaire (CUCQ)-32 was developed by reviewing the literature of the previously validated questionnaires and by consultation with patients and experts. Construct validity was carried out using the Short Form 12 and the EuroQol 5 dimensions questionnaires and two disease severity measures (the Simple Clinical Colitis Activity Index and the Harvey-Bradshaw Index). Test–retest analysis was done by asking patients to complete the CUCQ questionnaire twice within a period of two weeks.

Results:

Data were obtained from 205 patients with IBD who completed the CUCQ-32. Psychometric analysis showed that Cronbach’s α was 0.88, item–total correlations were good, and there were no ceiling or flooring effects. Stepwise regression identified eight items that accounted for >95% of the variance in the CUCQ-32. The resulting CUCQ-8 demonstrated good internal consistency (Cronbach’s α = 0.84), had good reproducibility (intraclass correlation coefficient = 0.94), was well correlated with the EuroQol 5 dimensions questionnaire (r = 0.58) and the Short Form-12 (r = 0.65 for physical component and r = 0.63 for mental component), and was responsive to change (responsiveness ratio was 0.64, p-value < 0.05).

Conclusions:

CUCQ-8 is a short questionnaire that has the potential to be an efficient tool for assessing the QoL of all patients with IBD in clinical practice.

Keywords: Inflammatory bowel disease; Crohn’s disease; colitis; quality of life

Journal Article.  8765 words. 

Subjects: Medicine and Health ; Clinical Medicine ; Gastroenterology ; Gastro-intestinal and Colorectal Surgery ; Health, Illness, and Medicine

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