Journal Article

Surgical Treatment in Childhood-onset Inflammatory Bowel Disease–A Nationwide Register-based Study of 4695 Incident Patients in Sweden 2002-2014

Caroline Nordenvall, Oda Rosvall, Matteo Bottai, Åsa H Everhov, Petter Malmborg, Karin E Smedby, Anders Ekbom, Johan Askling, Jonas F Ludvigsson, Pär Myrelid and Ola Olén

in Journal of Crohn's and Colitis

Published on behalf of European Crohn's and Colitis Organisation

Volume 12, issue 2, pages 157-166
Published in print January 2018 | ISSN: 1873-9946
Published online September 2017 | e-ISSN: 1876-4479 | DOI: https://dx.doi.org/10.1093/ecco-jcc/jjx132
Surgical Treatment in Childhood-onset Inflammatory Bowel Disease–A Nationwide Register-based Study of 4695 Incident Patients in Sweden 2002-2014

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  • Epidemiology
  • Gastroenterology
  • Paediatrics
  • Gastro-intestinal and Colorectal Surgery

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Abstract

Background and Aims

The incidence of childhood-onset [< 18 years] inflammatory bowel disease [IBD] is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and whether the improved medical treatment has influenced the need for gastrointestinal surgery. The aim was to examine whether the surgical treatment at any age of patients with childhood-onset IBD has changed over time.

Methods

In a nationwide cohort study we identified 4695 children [< 18 years] diagnosed with incident IBD in 2002–2014 through the Swedish Patient Register [ulcerative colitis: n = 2295; Crohn’s disease: n = 2174; inflammatory bowel disease-unclassified: n = 226]. Abdominal [intestinal resections and colectomies] and perianal surgeries were identified through the Swedish Patient Register. The cumulative incidences of surgeries were calculated using the Kaplan-Meier method.

Results

In the cohort, 44% were females and 56% males. The median age at inflammatory bowel disease diagnosis was 15 years and the maximum age at end of follow-up was 31 years. The 3-year cumulative incidence of intestinal surgery was 5% in patients with ulcerative colitis and 7% in patients with Crohn’s disease, and lower in children aged < 6 years at inflammatory bowel disease diagnosis [3%] than in those aged 15–17 years at diagnosis [7%]. Calendar period of inflammatory bowel disease diagnosis was not associated with risk of surgery.

Conclusion

Over the past 13 years, the risk of surgery in childhood-onset inflammatory bowel disease has remained unchanged.

Keywords: Children; inflammatory bowel disease; surgery

Journal Article.  6171 words.  Illustrated.

Subjects: Epidemiology ; Gastroenterology ; Paediatrics ; Gastro-intestinal and Colorectal Surgery

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