Journal Article

Alternative approach for right ventricular failure after left ventricular assist device placement in animal model

Tomohiro Saito, Koichi Toda, Yoshiaki Takewa, Tomonori Tsukiya, Toshihide Mizuno, Yoshiyuki Taenaka and Eisuke Tatsumi

in European Journal of Cardio-Thoracic Surgery

Published on behalf of European Association for Cardio-Thoracic Surgery

Volume 48, issue 1, pages 98-103
Published in print July 2015 | ISSN: 1010-7940
Published online October 2014 | e-ISSN: 1873-734X | DOI: https://dx.doi.org/10.1093/ejcts/ezu364
Alternative approach for right ventricular failure after left ventricular assist device placement in animal model

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  • Anatomy
  • Cardiovascular Medicine
  • Transplant Surgery

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OBJECTIVES

Right ventricular failure after left ventricular assist device (LVAD) implantation is associated with high mortality. This study was designed to evaluate the effectiveness of an atrial septostomy with a membrane oxygenator incorporated in an LVAD as a novel approach for right ventricular failure after LVAD implantation.

METHODS

The outflow and inflow cannulae were placed in the carotid artery and left ventricular apex, respectively. A centrifugal pump and an oxygenator were sequentially placed between the inflow and outflow cannulae in seven anesthetized goats. While right ventricular failure was induced by pulmonary artery banding, a balloon atrial septostomy was performed using a 19-mm balloon catheter under echocardiographic guidance. We investigated the effects of the interatrial shunt on LVAD flow and haemodynamics.

RESULTS

Development of right ventricular failure decreased LVAD flow (2.7 ± 0.6–0.9 ± 0.6 l/min), causing a state of shock [mean arterial pressure (MAP) of 41 ± 12 mmHg]. Following a balloon atrial septostomy, LVAD flow and MAP were significantly improved to 2.7 ± 0.4 l/min (P < 0.001) and 53 ± 18 mmHg (P = 0.006), respectively, while right atrial pressure decreased from 18 ± 5 to 15 ± 5 mmHg (P = 0.001). Furthermore, arterial blood oxygenation was maintained by the membrane oxygenator incorporated in the LVAD.

CONCLUSIONS

In the present model of right ventricular failure after LVAD implantation, LVAD flow was significantly increased and haemodynamics improved without compromising systemic oxygenation by the use of an interatrial shunt and a membrane oxygenator incorporated in the LVAD. Our results indicate that this novel approach may be less invasive for a right ventricular failure after LVAD implantation.

Keywords: Circulatory assist device; Animal model; Heart failure; extracorporeal membrane oxygenation

Journal Article.  3803 words.  Illustrated.

Subjects: Anatomy ; Cardiovascular Medicine ; Transplant Surgery

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